How to classify pharmaceutical intermediates?-Chuangxin Chemical Co., Ltd.

2022

08-29

Analysis of the current situation and development prospect of pesticide intermediates industry

Pesticide intermediates are fine chemicals. Pesticide intermediates are processed and produced from agricultural raw materials, and are an intermediate medium that combines two or more substances together. With the development of new pesticides in the country, the development of some special intermediates is rapid, such as fluorine-containing, cyano-containing and heterocyclic-containing intermediates, among which the more prominent are pyrethroid pesticide intermediates, such as chrysanthemic acid, dichloro Chrysanthemum acid, butyric acid, ether aldehyde, allyl ketone. The production sites of such intermediates are currently mainly concentrated in Shanghai, Zhejiang and Jiangsu. The upstream of pesticide intermediates are inorganic raw materials such as yellow phosphorus and liquid chlorine, and basic organic raw materials such as methanol triphenyl, which are used in the fields of agriculture, forestry, animal husbandry and sanitation after being made into pesticide technical drugs. Agricultural intermediates are located in the middle of the industrial chain and belong to the fine chemical industry, which is highly dependent on technology, has large R&D investment, long cycle, high risk and low success rate. The annual production capacity of major enterprises producing pesticide intermediates in my country is also declining. Take glycine, the intermediate of glyphosate, the world's largest pesticide variety, as an example. The main domestic glycine manufacturers are concentrated in Donghua Jinlong in Hebei, Donghua Jiheng in Donghua and Hengtai in Linyi in Shandong. The total production capacity accounts for more than 55% of the domestic effective production capacity, and the sales volume accounts for more than 60% of the domestic glycine market circulation. According to the production process of glycine, more than 3 tons of waste water will be produced for every ton of product produced. In the process of waste water treatment, the recovery of ammonium chloride consumes a lot of energy and is highly corrosive to equipment. , the secondary steam condensate still contains a large amount of pollutants. Tested by the National Environmental Analysis and Testing Center, the content of highly toxic substances in wastewater exceeds the national wastewater discharge standard by dozens to hundreds of times. In addition to the wastewater generated during the production process, waste gas is also generated during the glycine production process. Therefore, the production of glycine has been affected by the policy and has declined.

2022

08-29

Pharmaceutical intermediate customization and application

my country is the main producer and supplier of customized pharmaceutical intermediates, and the development prospects are very broad. Among them, 1,2,4-trichlorobenzene, o-cresol, catechol, and nonylphenol are the most important pesticide intermediates. 1,2,4-Trichlorobenzene is mainly used in the synthesis of pesticides dicamba, acaricidal sulfone, sodium pentachlorophenate, pentachlorophenol, etc.; o-cresol is mainly used in the synthesis of high-efficiency herbicides; catechol is an important The intermediates of low toxicity and high efficiency new carbamate pesticides carbamate, propoxur and acetocarb; nonylphenol is a multi-purpose nonionic surfactant, widely used in pesticide emulsifiers; m-cresol is mainly used in for the synthesis of pesticides and insecticides. In recent years, due to the gradual strengthening of the development and application of its downstream products at home and abroad, there is a strong demand for high-purity 1,2,4-trichlorobenzene in the international market. In addition, due to the prohibition and restricted use of lindane, traditional trichlorobenzene raw materials and the production of organochlorine products are gradually decreasing in developed countries and regions abroad, which has also led to the current global trichlorobenzene, especially high-purity 1 , 2,4-trichlorobenzene supply is tight. These factors have provided a good opportunity for the production and development of 1,2,4-trichlorobenzene in my country. The new carbamate insecticides produced by catechol, such as carbofuran, propoxur, acetaminophen, etc., are recommended by the World Health Organization as one of the household pests and storage pest control agents due to their low toxicity and good effect. The high-quality varieties, the market demand will also gradually increase. Nonylphenol is the most bulk product among alkylphenols. It has good functions such as decontamination, wetting and penetration, dispersion, solubilization and emulsification. It is widely used in pesticide emulsifiers. important intermediate. As for the market demand for m-cresol, the growth rate is basically maintained at an average annual level of 8% to 10%, and the development speed is stable. In addition, because fine chemical industry has the advantages of functionalization, high performance, special flowers, and high added value, it is a low-carbon and environment-friendly process, and it is a way to achieve the energy saving and emission reduction goals proposed by the state and develop a low-carbon economy. There is always a path, and the country's attention to it has greatly increased. It is also very beneficial to the development of the fine chemical pesticide intermediate industry. Therefore, my country's fine chemical pesticide and pharmaceutical intermediates industry has a very good development prospect under the double favorable influence of the increase in market demand and the government's encouragement of development.

2022

08-29

my country's pesticides and pesticide intermediates

I. Industry Overview of Pesticide and Pesticide Intermediates Pesticide refers to the chemicals used to control pests, weeds and pathogens that harm crops. The complete pesticide industry chain consists of three major sections: pesticide intermediates, pesticide technical synthesis and preparation processing. The upstream of the industry is yellow phosphorus, liquid chlorine and other inorganic raw materials and the basic end of methanol chemical industry, benzene chain production of three industries, etc. The organic raw materials are refined materials, and the detailed chemical industry is agriculture, forestry and animal husbandry, and the industry is related to biotechnology. The field of obstetrics and health dependence is large. The total investment in research and development is said to be large, and the industry is long-term in the agricultural and pharmaceutical period. The risk is high, and the success rate is low. T

2022

08-29

Overview and precautions of pesticide intermediates!

Overview: A pesticide intermediate is a product produced by processing agricultural raw materials, and is an intermediate medium that combines two or more substances. In pesticides, it can be understood as a synergist, which is an intermediate material for the production of pesticides. Common types: Plant growth regulators: diethyl aminoethyl hexanoate (DA-6), chlorfenuron (KT-30), sodium nitrophenolate, 6-BA, cytokinin, sodium α-naphthalene acetate, 5-nitrocarbamate Sodium fumarate, indole butyric acid, etc. Pesticide intermediates can be understood as synergists in pesticides, which are intermediate materials for the production of pesticides. That is, the product produced by the processing of agricultural raw materials is an intermediate medium that combines two or more substances. In my country, pesticide intermediates can generally be divided into two categories, pesticide intermediates containing heterocycles and pesticide intermediates containing fluorine. Precautions: 1. The medicine should be stored in a special warehouse, and a special person is responsible. Each drug is marked with obvious labels, and is stored in different categories according to the properties of the drug. All products are marked with the name, specification, quantity, ex-factory date, and storage time. 2. Improve the issuing system, the variety and quantity of pharmaceuticals should be approved by the supervisor, and the drug storehouse certificate will be issued. 3. Once the medicine is received, the operation team should designate a special person to keep and prepare it to prevent loss; after the operation is completed, all the remaining medicines will be returned to the medicine warehouse on the same day, and it is strictly forbidden to store them outside the warehouse. 4. The medicament must be stored in a cool, ventilated and dry place and strictly separated from food and water sources; fire and theft; oil and emulsion must be antifreeze. The packaging materials of the medicines will be taken back after one year and dealt with in a centralized manner. Don't litter randomly.

How to classify pharmaceutical intermediates?

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